domenica 10 giugno 2018

Gli interventi del 7° NBG meeting: "Le malattie del sistema nervoso"

Sono scaricabili i power points degli interventi cliccando sul nome del Relatore:

Andria: The Italian Research in the field of Rare Diseases of CNS

Auricchio: Gene therapy of inherited retinal degenerations.

Banfi: The molecular bases of inherited retinal degenerations

Riccio: Autism spectrum disorders: novel drug targets

Brunetti-Pierri: Whole Exome Sequencing in undiagnosed disease patient

Carotenuto: MicroRNAs to Monitor Pain-migraine and Drug Treatment

de Bartolomeis: Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes

Filla: Inherited ataxias: insights into their genetic bases

Micalizzi: Strategies for genetic diagnosis in pediatric neurological disorders: the example of congenital cerebellar malformations.

Riccio: Autism spectrum disorders: novel drug targets

Santoro: Molecular bases of inherited peripheral neuropathies

Taglialatela: Developmental encephalopathies and potassium channel mutations: from molecular mechanisms to personalized treatments

Tedeschi: Neuronal networks: an invisible manifestation of disea

Vezzani: Neuroinflammation and epilepsy: a basis for new therapeutic options


lunedì 21 maggio 2018

Settimo meeting del Neapolitan Brain Group: corso ECM riservato agli studiosi dell'AOU


Malattie del sistema nervoso, al via il corso ECM con il settimo meeting del Neapolitan Brain Group
articolo scritto da Alessandra Dionisio
Appuntamento giovedì 31 maggio, a partire dalle ore 9.00 alle 18.00 presso l’Aula T8 del CESTEV-Centro di servizio di ateneo per le Scienze e Tecnologie per la Vita (via T. De Amicis, 95) con l’evento formativo, accreditato ECM: “Le malattie del Sistema Nervoso: basi patogenetiche e nuovi approcci terapeutici”.
L’evento rappresenta il VII meeting del Neapolitan Brain Group. Il gruppo NBG, nato nel 2015 da un’idea di Ennio Del Giudice, afferente al DAI Materno Infantile dell’Azienda Ospedaliera Universitaria Federico II e Direttore della Scuola di Specializzazione in Neuropsichiatria Infantile della Scuola di Medicina e Chirurgia, è costituto da ricercatori di base e clinici dell’area napoletana, e più in generale, campana, interessati allo studio della fisiologia e delle patologie del sistema nervoso. Il gruppo è aperto a tutti e, in particolare, ai giovani in formazione, quali dottorandi, postdoc, specializzandi, studenti e tirocinanti delle Università e degli Enti di Ricerca. Il Neapolitan Brain Group rappresenta un’occasione di incontro, in un’atmosfera informale, per tutti gli appassionati di ricerca clinica e di base che intendano migliorare la reciproca conoscenza e esplorare momenti di collaborazione proficua con la finalità di unire in una rete culturale tutti i Centri dell’area campana in cui si fa clinica e/o ricerca di base nel settore delle neuroscienze e favorire lo scambio culturale tra  ricercatori giovani e colleghi più esperti.
Il corso intende dare una panoramica sulla patogenesi molecolare di malattie del sistema nervoso e sull’impatto che le nuove metodiche della diagnostica molecolare di tali patologie stanno avendo sulla pratica clinica. In particolare, utilizzando una strategia trasversale, i docenti illustreranno i nuovi precorsi di diagnosi ed impostazione della terapia in diversi ambiti della neurologia e della neuropsichiatria.
L’evento è strutturato in 4 sessioni: le malattie dell’occhio e della retina, l’epilessia e le sindromi epilettiche, i nuovi geni responsabili delle malattie del sistema nervoso centrale e infine le malattie psichiatriche. Una grande enfasi sarà data alle sindromi genetiche di interesse pediatrico, anche tenendo conto della rilevanza che esse hanno nella scoperta di nuovi meccanismi di malattia. Tra gli argomenti che verranno trattati sono in programma anche foscus sulle metodiche di FMRI che stanno rappresentando un importante strumento per gli studi in neurofisiopatologia perché permettono lo studio in vivo nell’uomo, in maniera non invasiva, di network neuronali. Ogni sessione vedrà alternarsi clinici e ricercatori di base dell’Ateneo Federico II e di prestigiosi Istituti di ricerca italiani come il Tigem di Pozzuoli, l’IGB-CNR di Napoli, l’Istituto di Ricerche Farmacologiche Mario Negri di Milano.
Data la molteplicità delle tematiche che verranno affrontate il corso è diretto non solo agli specialisti in neurologia ma anche agli psichiatri, ai neuropsichiatri infantili, ai pediatri, agli oculisti e agli specialisti in Medicina Interna e Medicina di Laboratorio, nonché a biologi, psicologi e specialisti delle Scienze Riabilitative delle Professioni Sanitarie.
Il programma dettagliato è reperibile al seguente link:
http://areacomunicazione.policlinico.unina.it/wp-content/uploads/2018/05/Programma-NBG-31.05.2018.pdf
Per partecipare è necessario compilare la scheda di iscrizione scaricabile al seguente link:


mercoledì 18 aprile 2018

BRAYN

Primo congresso BraYn (Brainstorming Research Assembly for Young Neuroscientists) di giovani ricercatori che lavorano nell'ambito delle neuroscienze.

Il congresso si terrà a Genova, presso l'Ospedale Policlinico San Martino-Auditorium IST Nord, il 29-30 giugno. L'evento vedrà la conferenza di alcuni invited speakers di fama internazionale, accompagnata da 12 presentazioni orali brevi di dati originali di giovani ricercatori su argomenti di neuro-oncologia, neurodegenerazione, plasticità neurale e neuroinfiammazione.

Maggiori info su www.braynconference.com

lunedì 4 dicembre 2017

PROGRAMMA DEL 6th MEETING



PROGRAMMA

09.00 - 09.15 Presentazione dell'SZN e saluti del Presidente Roberto Danovaro, saluti del coordinatore dell’NBG Ennio Del Giudice

09.15 - 11.00 PRIMA SESSIONE 
Chair: P. Sordino (SZN), G. Andria (UNINA)
09.15-9.30: Brain metabolic DNA is synthesized by reverse trascription in cytoplasmic organelles (Rutigliano, UNINA)
09.30-9.45: Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo (Sarnataro, UNINA/CEINGE)
09.45-10.00: Characterization of smn-1 genetic interactors in a C.elegans SMA model (Santonicola, IBBR)
10.00-10.15:  Study of neural stem cell biology in a mouse model of Rett syndrome (Squillaro, UNINA2)
10.15-10.30:  Nerve regeneration in the cephalopod mollusc Octopus vulgaris: from images to discoveries (Imperadore, SZN)
10.30-10.45: Orexin and endocannabinoid morphological interactions in the brain of adult zebrafish (Imperatore, UNISANNIO/ICB)
10.45-11.00: Shutting down ranslation of Amyloid Precursor protein in early symptomatic hAPP mutan mice rescues the Alzheimer Disease phenotype (Borreca, IBCN)

11.00 - 11.30 COFFEE BREAK e POSTERS

11.30 - 13.00 SECONDA SESSIONE 
Chair: M. Cataldi (UNINA), G. Fiorito (SZN) 
11.30-11.45:  Protocadherins and their role in brain complexity – a tale from
Octopus (Styfhals, SZN)
11.45-12.00:  Evidence of increased oxidative stress in Pompe disease. A new therapeutic target? (Tarallo, UNINA/TIGEM)
12.00-12.15:  Inhibition of monoacylglycerol lipase terminates diazepamresistant status epilepticus in mice and its effects are potentiated by a ketogenic diet (Terrone, UNINA/M.Negri)
12.15-12.30:  Orexin-Aenhances dopaminergic signaling in the brain of obese mice (Tunisi, ICB/UNINA)
12.30-12.45:  Onecut gene function in the CNS of chordates: development and evolution (Locascio, SZN)
12.45-13.00:  Targeting neuronal proteostasis to treat the CNS in lysosomal storage diseases (Monaco, TIGEM)

13.00 - 13.30 LUNCH BREAK

13.30 - 14.00 SESSIONE POSTERS

14.00 - 15.30 TERZA SESSIONE 
Chair: E. Di Schiavi (IBBR), B. Franco (TIGEM)
14.00-14.15: Myoclonic Epilepsy of Unverricht and Lundborg (EPM1):
understanding the role of Cystatin b in human cerebral organoids (Pipicelli,
UNINA/Max Planck)
14.15-14.30: A rat model of perinatal stress: impact on gene expreession of glutamatergic postsynaptic density genes (Avagliano, UNINA)
14.30-14.45: Modulation of aging pathways as a therapeutic strategy for
Parkinson’s disease (Decressac, TIGEM) 
14.45-15.00: Alteration of endosomal trafficking is associated  with neurodegenerative diseases (Paladino, UNINA/CEINGE)
15.00-15.15: Effects of Methylcyclopentadienyl Manganese Trycarbonil on dopaminergic neurons in zebrafish (Fasano, SZN/UNISANNIO)
15.15-15.30: Striatonigral involvement in Fabry Disease: a quantitative and volumetric MRI study (Russo, UNINA)

15.30 - 16.00 COFFEE BREAK (to be confirmed) e POSTERS 

16.00 - 17.30 QUARTA SESSIONE 
Chair: C. Lucini (UNINA), M. Taglialatela (UNINA)
16.00-16.15: The inflammatory response following acute seizures in zebrafish brain and in chordate evolution (Nittoli, SZN)
16.15-16.30: Pragmatic abilities in multiple sclerosis: an RS-FMRI study
(Cocozza, UNINA)
16.30-16.45: Default Mode Network modifications in Fabry Disease (Cocozza,
UNINA)
16.45-17.00: Brain functional changes and cognitive dysfunction in Friedreich's
Ataxia (Cocozza, UNINA)
17.00-17.15: Dissecting PRUNE-1/NME1 function in brain and cerebellum of
Microcephaly and Peho syndrome affected patients (Zollo, UNINA/CEINGE) 17.15-17.30: De novo gain-of-function variants in the Slo2 family of Na+activated K+ channels are responsible for developmental and epileptic encephalopathies (Manocchio, UNIMOL)


17.30 CONCLUDING REMARKS E. Del Giudice    

mercoledì 11 ottobre 2017

LETTERA D'INVITO ALL'INCONTRO DEL 14 DICEMBRE

Cari colleghi ed amici, 
è passato poco meno di un anno dal 5° meeting del Neapolitan Brain Group che è coinciso con la Prima Giornata d’incontro delle Neuroscienze dell’area Napoletana. Grazie alla partecipazione di tutti voi, il meeting è stato un grande successo, con circa 50 abstract sottomessi ed è stato un momento di stimolante interazione culturale nell’ambito delle neuroscienze. Visto il successo della passata edizione, apriamo una call for abstracts per il prossimo incontro, che si terrà il 14 Dicembre 2017 nella splendida cornice della Stazione Zoologica Anton Dohrn di Napoli (SZN), grazie alla disponibilità del suo Presidente Prof. Roberto Danovaro. Questo meeting è in linea con la filosofia che fin dall’inizio ha ispirato l’NBG ovvero promuovere la conoscenza e l’interazione tra tutti coloro che a Napoli ed in Campania condividono l’amore per l’affascinante campo delle Neuroscienze. Abbiamo il privilegio di annoverare nel comitato scientifico studiosi di assoluto prestigio: i Proff. A. Cellerino (Scuola Normale Superiore di Pisa), E.M. Valente (Università di Pavia) e M.A. Hilliard (QBI Brisbane, Australia). Per la prima volta, quindi, possiamo avvalerci dell’amichevole aiuto anche di ricercatori stranieri a riconferma del fatto che l’NBG ed il suo meeting si ispirano ai più sani principi della scienza come comunità globale. Ci auguriamo anche che questa sia un’opportunità per far conoscere il nostro gruppo e, soprattutto, la fertile comunità dei neuroscienziati napoletani al di fuori della nostra nazione. Anche quest’anno abbiamo deciso di mantenere il format del congresso dell’anno scorso che è sostanzialmente simile a quello dei più classici, grandi appuntamenti internazionali nell’ambito delle neuroscienze. Avremo, quindi, una formale sottomissione di abstract e una loro successiva valutazione da parte dei membri del comitato scientifico. Il congresso sarà articolato in sessioni di comunicazioni orali e, quest’anno includerà anche una esposizione e discussione di poster. Prevediamo di includere nel programma della giornata 18 presentazioni orali e 20 poster. E’ prevista anche grazie al supporto della SZN la pubblicazione di un book of abstracts. La scelta di mantenere questo format è dettata anche dal desiderio che i meeting dell’NBG siano oltre che un occasione di incontro per i neuroscienziati campani anche uno strumento importante per i più giovani (studenti, dottorandi, specializzandi, post-doc) per fare esperienza sia in termini di esposizione che di successiva discussione in una audience specialistica e qualificata. Confidiamo nella vostra partecipazione e con questa call invitiamo tutti coloro che desiderano inviare i loro contributi a sottomettere il loro abstract, secondo la form allegata, entro il 27 Ottobre 2017 all’indirizzo mail: endelgiu@unina.it indicando la propria preferenza per una presentazione orale o in forma di poster. I contributi sottomessi saranno valutati dal comitato scientifico che si riserva un giudizio finale circa la loro accettabilità e l’assegnazione al format di comunicazione orale o di poster. Gli autori saranno informati entro il 25 Novembre circa l’accettazione delle loro proposte e la modalità di presentazione. 
Un caro saluto a tutti dagli organizzatori dell’evento, 
Ennio Del Giudice, Carla Lucini, Elia Di Schiavi,  Mauro Cataldi, Paolo Sordino

martedì 19 settembre 2017

6° Incontro del NBG

14 Dicembre 2017 
Stazione Zoologica di Napoli A. Dohrn

Invio degli abstracts entro il 27 Ottobre  a: endelgiu@unina.it

domenica 19 febbraio 2017

National meeting of PhD students in Neurosciences


National Meeting of PhD Students in Neuroscience:

 

New Perspectives in Neuroscience: Research Results of Young Italian Neuroscientists” 


organizzato dalla Società Italiana di Neuroscienze (SINS)


Centro Congressi Federico II in via Partenope 36, Napoli

Il meeting si propone di far conoscere i migliori progetti di ricerca che i Dottorandi delle varie sedi universitarie italiane stanno conducendo nell’ambito delle neuroscienze. Sul sito della SINS (http://www.sins.it/EN/index.xhtml) è disponibile il programma scientifico, per cui tutti i potenziali interessati possono prendere visione delle linee di ricerca proposte ed eventualmente partecipare al meeting.

venerdì 16 dicembre 2016

GRAZIE!


A nome  degli organizzatori dell'NBG grazie  a tutti coloro che hanno partecipato alla giornata straordinariamente ricca e stimolante del 15 Dicembre. 


Un grazie particolare al CEINGE, nelle persone dei Professori Franco Salvatore ed Alessandro Usiello, nonche' Vittorio Lucignano per il prezioso supporto tecnico. 


Vi diamo appuntamento al prossimo incontro nel 2017, che speriamo sia di pari successo!

lunedì 12 dicembre 2016

5° meeting del NBG

Le neuroscienze nell'area napoletana

15 Dicembre 2016


CEINGE Biotecnologie Avanzate s.c. a r.l. 

Via Gaetano Salvatore 486 (ex-Via Comunale Margherita), 
80131 Napoli, Italia



Comitato scientifico
 Ennio Del Giudice (UNINA), L. Annunziato (UNINA), A. Usiello (CEINGE), Carla Lucini (UNINA), Elia Di Schiavi (IBBR, CNR), Mauro Cataldi (UNINA)


sabato 3 dicembre 2016

Scopus news

D'Amico, A., Russo, C., Ugga, L., Mazio, F., Capone, E., D'Arco, F., Mankad, K., Caranci, F., Marano, E., Brunetti, A.
Can pontine trigeminal T2-hyperintensity suggest herpetic etiology of trigeminal neuralgia?
(2016) Quantitative Imaging in Medicine and Surgery, 6 (5), pp. 490-495. 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994884887&partnerID=40&md5=2fdd743482a13368be8211db3120995e

DOI: 10.21037/qims.2016.01.07
AFFILIATIONS: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, Italy; 
Department of Neuroradiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy
ABSTRACT: Background: Trigeminal neuralgia (TN) is usually classified into two different categories: idiopathic and secondary. We have investigated the frequency of brainstem pontine lesions in patients with idiopathic TN without multiple sclerosis (MS) or stroke, and their association with herpes zoster (HZ) infection. Methods: Brain magnetic resonance imaging (MRI) studies of 28 patients with TN were retrospectively reviewed. Results: We found seven patients with clinical suspicion of HZ infection and pontine T2 hyperintense lesions, associated with nerve atrophy in one case. Fifteen patients had a neurovascular conflict (NVC) without brainstem involvement, two of them associated with trigeminal atrophy, while four patients had only volumetric reduction of the nerve. In all patients MRI findings were ipsilateral to the side of TN. Conclusions: Pontine T2 hyperintensities could be considered as a MRI sign of TN in patients without NVCs. This "trigeminal pontine sign" (TPS) is frequently found in association with herpetic infections. © Quantitative Imaging in Medicine and Surgery. All rights reserved.
CORRESPONDENCE ADDRESS: D'Amico, A.; Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Italy; email: doctoralex@hotmail.it

Scopus news

D'Arco, F., Ugga, L., Caranci, F., Riccio, M.P., Figliuolo, C., Mankad, K., D'Amico, A.
Isolated macrocerebellum: Description of six cases and literature review
(2016) Quantitative Imaging in Medicine and Surgery, 6 (5), pp. 496-503. 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994845888&partnerID=40&md5=35ac344c9b639a7bb48fcc8b82974f91

DOI: 10.21037/qims.2016.06.10
AFFILIATIONS: Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 
Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy; 
Department of Mental and Physical Health and Preventive Medicine, Child and Adolescent Psychiatry Division, Second University of Naples, Caserta, Italy; 
Section of Pediatrics, Department of Translational Medical Science, University of Naples Federico II, Naples, Italy
ABSTRACT: Background: Macrocerebellum is a rare entity described as an isolated and abnormal increase of the cerebellum (CB) size without morphological or signal abnormalities. There have been only eleven patients with macrocerebellum reported in the literature so far. Methods: From December 2011 to March 2014, among 950 paediatric patients that underwent a magnetic resonance scan of the brain in our department, in six subjects an abnormal increase of the cerebellar volume was suspected. A volumetric analysis was performed in all patients on T1-weighted 3D imaging to confirm the diagnosis of macrocerebellum. The ratios between (I) volume of the CB and volume of the supratentorial structures (STB) and (II) volume of the CB and the sum of CB and STB (WB) were calculated in order to normalize the absolute values obtained and compared with the normal values present in literature. Results and Discussion: Quantitative analysis confirmed an increased cerebellar volume relatively to the STB volume ("t": 6.9518; P<0.001) and to the WB ("t": 7.1415; P<0.001) volume in comparison to the normal controls available in literature. Clinical characteristics and other neuroradiological findings of the patients are described. We also describe the differential features between isolated macrocerebellum and other pathological conditions that are characterized by cerebellar enlargement such as Lhermitte-Duclos, Sotos syndrome, Costello syndrome, Williams syndrome, Alexander disease and fucosidosis. Furthermore a detailed literature review is provided. Macrocerebellum is always associated with an abnormal mental and motor development. Conclusion: Macrocerebellum is a neuroradiological entity that can be identified qualitatively and confirmed quantitatively through volumetric analysis. This is the largest cohort of patients with macrocerebellum described so far. The data available in literature on this entity show that macrocerebellum is not a specific disease but an epiphenomenon found in heterogeneous brain disorders. © Quantitative Imaging in Medicine and Surgery. All rights reserved.
CORRESPONDENCE ADDRESS: D'Arco, F.; Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation TrustUnited Kingdom; email: darcofel@gmail.com

Scopus news

Rengo, G., Pagano, G., Filardi, P.P., Femminella, G.D., Parisi, V., Cannavo, A., Liccardo, D., Komici, K., Gambino, G., D'Amico, M.L., De Lucia, C., Paolillo, S., Trimarco, B., Vitale, D.F., Ferrara, N., Koch, W.J., Leosco, D.
Prognostic value of lymphocyte G protein-coupled receptor kinase-2 protein levels in patients with heart failure
(2016) Circulation Research, 118 (7), pp. 1116-1124. 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994571224&partnerID=40&md5=c040107e0a990576873a37b9e36f8191

DOI: 10.1161/CIRCRESAHA.115.308207
AFFILIATIONS: Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy; 
Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Via S. Pansini, 5, Naples, Italy; 
Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy; 
SDN Foundation IRCCS, Institute of Diagnostic and Nuclear Development, Naples, Italy; 
Department of Pharmacology, Center of Translational Medicine, Temple University School of Medicine, 3500 N Broad St., Philadelphia, PA, United States
ABSTRACT: Rationale: Sympathetic nervous system hyperactivity is associated with poor prognosis in patients with heart failure (HF), yet routine assessment of sympathetic nervous system activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulated in HF patients, causing dysfunctional β-adrenergic receptor signaling. Importantly, myocardial GRK2 levels correlate with levels found in peripheral lymphocytes of HF patients. Objective: The independent prognostic value of blood GRK2 measurements in HF patients has never been investigated; thus, the purpose of this study was to evaluate whether lymphocyte GRK2 levels predict clinical outcome in HF patients. Methods and Results: We prospectively studied 257 HF patients with mean left ventricular ejection fraction of 31.4±8.5%. At the time of enrollment, plasma norepinephrine, serum NT-proBNP, and lymphocyte GRK2 levels, as well as clinical and instrumental variables were measured. The prognostic value of GRK2 to predict cardiovascular (CV) death and all-cause mortality was assessed using the Cox proportional hazard model including demographic, clinical, instrumental, and laboratory data. Over a mean follow-up period of 37.5±20.2 months (range, 3-60 months), there were 102 CV deaths. Age, left ventricular ejection fraction, New York Heart Association class, chronic obstructive pulmonary disease, chronic kidney disease, N-terminal-pro brain natriuretic peptide, and lymphocyte GRK2 protein levels were independent predictors of CV mortality in HF patients. GRK2 levels showed an additional prognostic and clinical value over demographic and clinical variables. The independent prognostic value of lymphocyte GRK2 levels was also confirmed for all-cause mortality. Conclusions: Lymphocyte GRK2 protein levels can independently predict prognosis in patients with HF. © 2016 American Heart Association, Inc.
CORRESPONDENCE ADDRESS: Koch, W.J.; Department of Pharmacology, Center of Translational Medicine, Temple University School of Medicine, 3500 N Broad St., United States; email: walter.koch@temple.edu

Scopus news

Corbi, G., Conti, V., Davinelli, S., Scapagnini, G., Filippelli, A., Ferrara, N.
Dietary phytochemicals in neuroimmunoaging: A new therapeutic possibility for humans?
(2016) Frontiers in Pharmacology, 7, art. no. 364, . 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994323063&partnerID=40&md5=b54358b70025787c6be6ef1df3dbef65

DOI: 10.3389/fphar.2016.00364
AFFILIATIONS: Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 
Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy; 
Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy; 
Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese, Telese Terme, Italy
ABSTRACT: Although several efforts have been made in the search for genetic and epigenetic patterns linked to diseases, a comprehensive explanation of the mechanisms underlying pathological phenotypic plasticity is still far from being clarified. Oxidative stress and inflammation are two of the major triggers of the epigenetic alterations occurring in chronic pathologies, such as neurodegenerative diseases. In fact, over the last decade, remarkable progress has been made to realize that chronic, low-grade inflammation is one of the major risk factor underlying brain aging. Accumulated data strongly suggest that phytochemicals from fruits, vegetables, herbs, and spices may exert relevant immunomodulatory and/or anti-inflammatory activities in the context of brain aging. Starting by the evidence that a common denominator of aging and chronic degenerative diseases is represented by inflammation, and that several dietary phytochemicals are able to potentially interfere with and regulate the normal function of cells, in particular neuronal components, aim of this review is to summarize recent studies on neuroinflammaging processes and proofs indicating that specific phytochemicals may act as positive modulators of neuroinflammatory events. In addition, critical pathways involved in mediating phytochemicals effects on neuroinflammaging were discussed, exploring the real impact of these compounds in preserving brain health before the onset of symptoms leading to inflammatory neurodegeneration and cognitive decline.
CORRESPONDENCE ADDRESS: Corbi, G.; Department of Medicine and Health Sciences, University of MoliseItaly; email: graziamaria.corbi@unimol.it

Scopus news

Buonocore, M., Amarelli, C., Scardone, M., Caiazzo, A., Petrone, G., Majello, L., Santé, P., Nappi, G., Della Corte, A.
Cerebral perfusion issues in acute type A aortic dissection without preoperative malperfusion: How do surgical factors affect outcomes?
(2016) European Journal of Cardio-thoracic Surgery, 50 (4), pp. 652-659. 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994125586&partnerID=40&md5=581169a08d7a8119bbf95f6b81e538fa

DOI: 10.1093/ejcts/ezw152
AFFILIATIONS: Department of Cardiac Surgery, AZ Sint Jan, Brugge, Belgium; 
Department of Cardiovascular Surgery and Transplants, Monaldi Hospital, Azienda dei Colli, Naples, Italy; 
Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy; 
Unit of Neurology, Monaldi Hospital, Azienda dei Colli, Naples, Italy
ABSTRACT: OBJECTIVES: Both preoperative (disease-related) and operative (management-related) variables make the assessment of the outcomes of acute type A aortic dissection (ATAAD) surgery a difficult task. Our aim was to evaluate the impact of operative factors, including arterial cannulation site, route of cerebral perfusion and surgeon's specific experience with ATAAD ('aortic surgeon'), on the early results of surgical management, with particular attention to neurological injury. METHODS: Penn classification was used to identify clinically homogeneous risk groups of ATAAD patients undergoing surgery. Between January 2007 and June 2014, 111 of 183 ATAAD patients treated with open surgery in a single centre were in Penn Class Aa (no ischaemic complications at presentation). They were divided in two groups depending on the arterial cannulation site: femoral artery (FemA; 56 patients) or right axillary artery (RAxA; 55 patients). Study outcomes included: 30-day mortality, major adverse cardiac and cerebrovascular events at 30 days, neurological complications and in particular, patterns of stroke as defined by Bamford classification. RESULTS: No significant differences in preoperative variables were observed between cannulation-site groups, except for myocardial ischaemic time (60.9 ± 30.4 min in the RAxA group vs 81.7 ± 52.3 in the FemA group, P = 0.014) and cerebral perfusion time (42.1 ± 25.5 min in the RAxA group vs 52.9 ± 32.6 in the FemA group, P = 0.048). Outcomes in terms of mortality and neurological injury did not differ except for a higher incidence of lacunar cerebral infarction (LACI) in the RAxA group (14.5 vs 3.6%, P = 0.043), mainly but not exclusively explained by a higher incidence of LACI in unilateral (17.2%) than in bilateral cerebral perfusion (6.9%) within the RAxA group. The 'non-aortic surgeon' was associated instead with 30-day mortality and composite outcome in multivariable analysis (respectively, OR 6.40, P = 0.002 and OR 4.68, P = 0.001). CONCLUSIONS: The RAxA cannulation and FemA cannulation are associated with comparable 30-day mortality following surgery for aortic dissection. However, the possible higher risk of LACI-type strokes in the RAxA group, especially when associated with unilateral brain perfusion, should be considered when RAxA cannulation is performed in ATAAD. The hypothesis that more experienced surgeons may produce better earlier outcomes warrants further investigation. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
CORRESPONDENCE ADDRESS: Buonocore, M.; Department of Cardiac Surgery, AZ Sint Jan, Ruddershove 10, Belgium; email: mariannabuonocore@gmail.com

lunedì 21 novembre 2016

Scopus news


Makovac, E., Cercignani, M., Serra, L., Torso, M., Spanò, B., Petrucci, S., Ricciardi, L., Ginevrino, M., Caltagirone, C., Bentivoglio, A.R., Valente, E.M., Bozzali, M.
Brain connectivity changes in autosomal recessive Parkinson disease: A model for the sporadic form
(2016) PLoS ONE, 11 (10), art. no. e0163980, . 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992756733&partnerID=40&md5=4e8e604bbf4d95329d164c0d93487ac6
DOI: 10.1371/journal.pone.0163980
AFFILIATIONS: Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 
Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Falmer, Brighton, United Kingdom; 
IRCCS Casa Sollievo della Sofferenza, CSS-Mendel laboratory, San Giovanni Rotondo, Italy; 
Dept. of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; 
Sobell Dept. of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom; 
Dept. of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; 
Dept. of Neuroscience, University of Rome 'Tor Vergata', Rome, Italy; 
Dept. of Neurosciences, Catholic University, Rome, Italy; 
Section of Neurosciences, Dept. of Medicine and Surgery, University of Salerno, Salerno, Italy
ABSTRACT: Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of various neuronal circuits. Using resting-state functional MRI (RSfMRI), we tested the hypothesis that abnormal connectivity within and between brain networks may account for the patients' cognitive status. Eight homozygous and 12 heterozygous carriers of either PINK1 or Park2 mutation and 22 healthy controls underwent RSfMRI and cognitive assessment. RS-fMRI data underwent independent component analysis to identify five networks of interest: default-mode network, salience network, executive network, right and left fronto-parietal networks. Functional connectivity within and between each network was assessed and compared between groups. All mutation carriers were cognitively impaired, with the homozygous group reporting a more prominent impairment in visuo-spatial working memory. Changes in functional connectivity were evident within all networks between homozygous carriers and controls. Also heterozygotes reported areas of reduced connectivity when compared to controls within two networks. Additionally, increased inter-network connectivity was observed in both groups of mutation carriers, which correlated with their spatial working memory performance, and could thus be interpreted as compensatory. We conclude that both homozygous and heterozygous carriers exhibit pathophysiological changes unveiled by RS-fMRI, which can account for the presence/severity of cognitive symptoms. Copyright © 2016 Makovac et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Scopus news

Krashia, P., Ledonne, A., Nobili, A., Cordella, A., Errico, F., Usiello, A., D'Amelio, M., Mercuri, N.B., Guatteo, E., Carunchio, I.
Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons
(2016) Neuropharmacology, 103, pp. 69-78. 
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992268842&partnerID=40&md5=8a0e6f0d479c9bdad4fa2f1b344e4813

DOI: 10.1016/j.neuropharm.2015.12.013
AFFILIATIONS: Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; 
Department of Medicine, Unit of Molecular Neurosciences, University Campus-Biomedico, Rome, Italy; 
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 
Ceinge Biotecnologie Avanzate, Naples, Italy; 
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy; 
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples (SUN), Caserta, Italy
ABSTRACT: Dopamine neurons in the substantia nigra pars compacta regulate not only motor but also cognitive functions. NMDA receptors play a crucial role in modulating the activity of these cells. Considering that the amino-acid D-Aspartate has been recently shown to be an endogenous NMDA receptor agonist, the aim of the present study was to examine the effects of D-Aspartate on the functional properties of nigral dopamine neurons. We compared the electrophysiological actions of D-Aspartate in control and D-aspartate oxidase gene (Ddo-/-) knock-out mice that show a concomitant increase in brain D-Aspartate levels, improved synaptic plasticity and cognition. Finally, we analyzed the effects of L-Aspartate, a known dopamine neuron endogenous agonist in control and Ddo-/- mice. We show that D- and L-Aspartate excite dopamine neurons by activating NMDA, AMPA and metabotropic glutamate receptors. Ddo deletion did not alter the intrinsic properties or dopamine sensitivity of dopamine neurons. However, NMDA-induced currents were enhanced and membrane levels of the NMDA receptor GluN1 and GluN2A subunits were increased. Inhibition of excitatory amino-acid transporters caused a marked potentiation of D-Aspartate, but not L-Aspartate currents, in Ddo-/- neurons. This is the first study to show the actions of D-Aspartate on midbrain dopamine neurons, activating not only NMDA but also non-NMDA receptors. Our data suggest that dopamine neurons, under conditions of high D-Aspartate levels, build a protective uptake mechanism to compensate for increased NMDA receptor numbers and cell hyper-excitation, which could prevent the consequent hyper-dopaminergia in target zones that can lead to neuronal degeneration, motor and cognitive alterations. © 2015 Elsevier Ltd. All rights reserved.
CORRESPONDENCE ADDRESS: Guatteo, E.; Department of Experimental Neurology, IRCCS Santa Lucia FoundationItaly; email: e.guatteo@hsantalucia.it

mercoledì 16 novembre 2016

Seminario su "Infiammazione ed epilessia: meccanismi e conseguenze"

Mercoledi 23 novembre 2016 alle ore 16 

Policlinico universitario Federico II - via Pansini 5,  Aula grande dell’Edificio 11 di Pediatria 

 seminario di Annamaria Vezzani:

Infiammazione ed epilessia: meccanismi e conseguenze 

Annamaria Vezzani è Direttore del Laboratorio di Neurologia Sperimentale dell'Istituto di Ricerche Farmacologiche Mario Negri di Milano. La sua formazione si è svolta all'Università del Maryland a Baltimora, al Karolinska Institute di Stoccolma e all'Albert Einstein College of Medicine nel laboratorio dedicato a Developmental Epilepsy.
La sua principale linea di ricerca è tesa allo studio dei meccanismi biochimici e molecolari coinvolti nella patogenesi delle crisi epilettiche e nella epilettogenesi in modelli sperimentali. Le sue pubblicazioni contano più di 160 lavori originali e numerosi capitoli di libri (H-index 57). E' stata designata come Chair della Commissione sulla Neurobiologia della ILAE (International League against Epilepsy) che promuove iniziative per migliorare la ricerca traslazionale in epilettologia. Ha ricevuto il Research Recognition Award for Translational research dall'American Epilepsy Society.